![]() ![]() When the skin barrier is disrupted, a cascade of cellular and molecular events is activated to repair the damage and restore skin integrity. The skin epidermis is a stratified epithelium that acts as a barrier protecting the animals against infections, trauma and water loss 1. These results have important implications for tissue regeneration, acute and chronic wound disorders. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitors that expand and repair the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. Tania Sarafian: The End of Year Showcase is a fantastic opportunity for the students to share what they’ve learnt through the STEM Community Partnerships Programme.Wound healing is essential to repair the skin after injury. Programmes like STEM Community Partnerships Programme enables students to see industry and STEM in real life and that’s what makes it real and makes it exciting. Ruth Carr: The future is about nurturing the next generation of problem solvers and innovators and that’s what Generation STEM is all about. I, I just think our future is in very, very safe and capable hands. There were boys and there were girls and they, and there was no difference to their passion. What I loved about it were there were, it wasn’t gender heavy. It embodies hope and it’s hope for our futureĪnd when you talk to the, to the students who have taken part in this STEM project they are truly excited about the future and so that, that really excites me. Margaret Chivers: The STEM Community Partnership Programme is exciting. So, it’s so important that we teach and inspire the next generation.Ĭr. Lauren Klein: STEM is real and it shows them that science and maths, engineering and technology don’t stand alone.Ĭharles Elbayeh: Without the next generation of scientists and engineers we’re not going to grow. With an understanding of STEM the future is limitless. I would love to be part of the future generation that contributes a lot to science.Ĭalvin: STEM is the most vital thing you could ever have. Joanne: I would love to consider a career in STEM because So, it’s definitely something that I’ll consider in the future. Nikie: I think after leaving this project this has really help me ease into the world of STEM. It allows the students to become more engaged in schools and solve problems that are actually relevant to our community. We’re really paving the way to future generations with this programme.Ĭharles Elbayeh: Being a mentor, I really hope that I can give the students a really good understanding of industry. Lauren Klein: Having a connection with industry it means that they see it as real and they see it as a possibility for their future.Ĭhristopher Guthrie: It provides students with the opportunity to talk directly with businesses, be mentored by businesses. You know, it was great gathering all perspectives and also incorporating our own to create a very innovative and accommodating solution for everybody. See, I think the most exciting thing about the project overall is that we were able to collaborate with not only our classmates but also talk to many of the people outside our usual social circle. So, it was really exciting to have that opportunity and it was thrilling to experience that. Nikie: It’s so exciting to live in a STEM and a technologically driven world, especially as young people today where we interact with it everyday but we don’t really know the real mechanics behind it and how it works. I’ve loved watching them create solutions to problems.Ĭalvin: STEM for me is helping our community be more sustainable and understanding that STEM is really vital in everyone’s lives. Lauren Klein: Our students have such curiosity and such creativity and this has allowed them to shine. They’ve been able to really think outside the square and have a bit of fun. Narelle Archer: We have loved being a part of the CSIRO STEM Community Partnership Programme.
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